témavezető: Mihály József
helyszín (magyar oldal): BRC HAS, Institute of Genetics and University of Liverpool, Institute of Translational Medicine helyszín rövidítés: SzBK
A kutatási téma leírása:
The non-canonical Wnt/PCP pathway has recently emerged as an important factor in Alzheimer’s disease (AD). Genetic studies linked the Wnt pathway with late-onset AD, also it was shown that Amyloid-ß (Aß) inhibits Wnt signalling, and enhanced Wnt signalling is neuroprotective in AD models. However, although the cell biology downstream of Wnt/PCP signalling linking to neuronal loss may provide important therapeutic opportunities, it remained poorly understood. To study this important aspect, we want to capitalise on the fact that the Wnt/PCP pathway is evolutionary well conserved and it is experimentally highly amenable in Drosophila. We plan to exploit our former finding that the Wnt/PCP pathway interacts with the actin assembly factor DAAM; our experience with studying the roles of DAAM during neuronal actin regulation; as well as our knowledge of the neuronal cytoskeleton and synapses in the context of neurodegeneration.
During this project, the student will assess (1) how up/down regulation of Wnt/PCP pathway components affects neuronal longevity and relevant cell biological features (cytoskeleton, axonal transport, synapses) in fly models of AD and (2) identify molecular mechanisms which link the Wnt/PCP pathway to these cellular changes. Objective 1 will be carried out in Liverpool, objective 2 in Szeged within the framework of a Dual PhD Programme of the Universities of Liverpool and Szeged, and the student will receive intensive training in genetics, cell biology, imaging and biochemistry.
The concept of this research is novel and promising, and it provides new opportunities to deliver mechanistic explanations for the emerging links between Wnt signalling and AD as well as novel potential therapeutic targets.
In cooperation with BRC HAS and Institute of Genetics and University of Liverpool, Institute of Translational Medicine (Dr. Natalia Sanchez-Soriano)
előírt nyelvtudás: angol további elvárások: Experience in Drosophila genetics and/or neurobiology will be advantegous
felvehető hallgatók száma: 1
Jelentkezési határidő: 2015-10-13
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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