témavezető: Krizbai István
társ-témavezető: Wilhelm Imola
helyszín (magyar oldal): MTA Szegedi Biológiai Kutatóközpont, Biofizikai Intézet helyszín rövidítés: SzBK
A kutatási téma leírása:
Brain metastases of malignant tumors are life threatening pathologies with limited therapeutic options. Therefore, besides surgical removal of the primary tumor, suppressing or reducing the risk of metastasis formation could be one of the most effective approaches in the therapeutic strategies. Since the CNS lacks a lymphatic vasculature, the only possibility for cancer cells to reach the brain is via the blood stream. Metastatic cells invading the CNS parenchyma thus have to pass the blood-brain barrier (BBB). Tumors giving CNS metastases with the highest frequencies are malignant melanoma, lung cancer and breast cancer. By using an in vitro model of the BBB the project is focused on the elucidation of molecular mechanisms by which cancer cells cross the BBB. Different molecular, biochemical and immunofluorescent techniques will be applied to elucidate the role of various signaling mechanisms, proteolytic enzymes and brain derived factors in the transmigration of metastasizing cancer cells. In vivo, advanced microscopic techniques (two photon microscopy) will be applied to monitor the process of transmigration.
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