Bejelentkezés
 Fórum
 
 
Témakiírás
 
Csortos Csilla
Investigation of the protein phosphatase 1-TIMAP complex in endothelial cells

TÉMAKIÍRÁS

Intézmény: Debreceni Egyetem
elméleti orvostudományok
Molekuláris Orvostudomány Doktori Iskola

témavezető: Csortos Csilla
helyszín: DE ÁOK Orvosi Vegytani Intézet
helyszín rövidítés: DEOVI


A kutatási téma leírása:

The vascular endothelium serves as a selective barrier to fluid and solute flux across the blood vessel walls. Dephosphorylation of phosphoproteins by phospho-Ser/Thr-specific protein phosphatases is crucial in the regulation of endothelial barrier function. Our goal is to learn about the regulatory role of protein phosphatase (PP) 1 on endothelial barrier function in the lung and in the brain, through its regulatory/interacting protein partners. TIMAP (TGFβ-inhibited membrane associated protein), a member of the MYPT family of PP1 targeting subunits, is indeed a regulatory subunit of PP1. While MYPT1 has been extensively studied, much less is known about TIMAP. TGF-β represses TIMAP in endothelial cells, but TGF-β was also shown to be upregulated in the brain in multiple sclerosis, Alzheimer’s disease, stroke, tumors, or trauma. Therefore, our research will be focused on the hypothesis that TIMAP, as a regulatory subunit of PP1, is an active participant in establishment/maintenance of the blood brain barrier. Besides, we aim to widen our knowledge on new protein partners of TIMAP in EC.

előírt nyelvtudás: angol középfok
felvehető hallgatók száma: 1

Jelentkezési határidő: 2016-11-01

 
Minden jog fenntartva © 2007, Országos Doktori Tanács - a doktori adatbázis nyilvántartási száma az adatvédelmi biztosnál: 02003/0001. Program verzió: 1.2318 ( 2016. XI. 26. )