Thesis supervisor: Géza Fogarasi
Location of studies (in Hungarian): TTK Kémiai Intézet Abbreviation of location of studies: Kém.
Description of the research topic:
A fundamental goal of molecular biochemistry is to understand the structure and functioning of the four bases in nucleic acids. A vast number of studies, both experimental and especially computational, have dealt with questions like isomerization-tautomerization, intermolecular interactions etc., but many details are still open for study.
An important special question is the role of water (water molecules surrounding the DNA in vivo) in determining structure. Following studies by the supervisor in the past decade, the PhD student would do independent research on hydration, using two approaches: microhydration (a few water molecules added to a base explicitly, thus forming a supermolecule); the base within a cluster of (several hundred) water molecules, treated as a quantum mechanical / molecular mechanics (QM/MM) system.
Required language skills: angol Number of students who can be accepted: 1
Deadline for application: 2014-11-27
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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