Thesis supervisor: Csilla Laczka
Location of studies (in Hungarian): Institute of Enzymology, RCNS, HAS, Budapest (MTA TTK) Abbreviation of location of studies: MTA
Description of the research topic:
Organic Anion Transporting Polypeptides (OATPs) are membrane proteins that mediate the uptake of large anionic or amphipatic organic molecules. In addition to their transport of endogenous compounds (bile acids and various hormones), several members of the family are also able to transport clinically applied drugs. Therefore OATPs may influence the in vivo fate of drugs. In addition to their physiological relevance, altered expression or function of OATPs has also been documented in cancer and inflammation. Hence OATPs are potential targets in anti-cancer or anti-inflammatory therapy. Our group focuses on the comprehensive biochemical characterization of OATPs, including structure-function studies and the screening of potential OATP substrates and inhibitors.
Required language skills: english (at least B2 level) Further requirements: "MSc in health sciences
experience in molecular and cell biology techniques
diligence
good communication skills (English at least B2 level)
enthusiasm
motivation
"
Number of students who can be accepted: 1
Deadline for application: 2017-05-31
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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