Thesis supervisor: Ágnes Enyedi
Location of studies (in Hungarian): Molecular Oncology Research Group of the Hungarian Academy of Sciences and Semmelweis University, 2nd Institute of Pathology, Budapest, Hungary Abbreviation of location of studies: MTA
Description of the research topic:
Migration of tumor cells often leads to tumor-cell invasion and metastasis, which is the major cancerous process that causes death. This project is focusing on the molecular mechanisms by which cytosolic calcium controls migration of tumor cells. The specific aims are 1. to study spatial organization of calcium signaling molecules in melanoma and breast cancer cell types; 2. to determine specific trafficking and sorting motifs in these molecules; 3. to study cytoskeletal dynamics and cell shape at different conditions; and 4. to study local and global calcium signaling by using genetically encoded calcium indicators. Proper control of cellular calcium homeostasis is critical for cell physiology; any disturbances in this pathway can result in the development of diseases such as cancer and metastasis. Therefore, understanding the role of calcium signaling elements in cell migration can provide information that may lead to new therapy options of metastatic cancer.
Required language skills: english (at least B2 level) Recommended language skills (in Hungarian): not reqiured Further requirements: "Experience with essential laboratory techniques: gelelectrophoresis, Western blot, cell culture techniques
Exprerience in statistics and computer skills (MS Excel and other MS Office applications)
"
Number of students who can be accepted: 1
Deadline for application: 2017-05-31
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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