Thesis supervisor: István Tóth
Location of studies (in Hungarian): Institute for Veterinary Medical Research, Agricultural Research Center, Hungarian Academy of Sciences Abbreviation of location of studies: MTA
Description of the research topic:
Bacteriophages (shortly phages) are the most abundant organisms in the biosphere, and have been playing a leading role in the evolution of bacteria. Several virulence genes, first of all toxin genes are frequently located in the genome of phages, and these genes may spread by horizontal gene transfer(HGT). Non pathogenic strains can be converted to pathogenic ones or pathogenic strains could gain higher virulence by HGT. Additionally to the free lytic phages, a great number of integrated phages, termed temperated prophages have been discovered by bacterial genomes’ sequence analysis. This knowledge provides a suitable basis for a doctoral programme aiming to isolate and characterize phages from different environmental and food sources as well as from bacterial isolates of human and animal origin. Our object is to set up a phage collection and conduct phenotypic (morphology, bacterial host specificity) and genotypic characterization of phages. As a main goal, determination of phages’ host specificity will promote the development of diagnostic and typing methods in bacteriology (phage typing). Identification of phages effective against multi drug resistant (MDR) bacteria would promote an alternative strategy (phage therapy) against MDR strains.
Required language skills: english (at least B2 level) Further requirements: MSc in biology and pharmaceutics or DVM, MD. Scientific curiosity and dedication,
Number of students who can be accepted: 1
Deadline for application: 2017-05-31
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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