Thesis supervisor: Zoltán Varga
Location of studies (in Hungarian): Research Centre for Natural Sciences Abbreviation of location of studies: MTA
Description of the research topic:
Extracellular vesicles (EVs) are key players of the intercellular communication, but they received attention only in recent years. EVs are phospholipid bilayer enclosed structures that can carry proteins and nucleic acids, but they are also capable of serving the secretion of toxic molecules. The idea of using EVs as biomarkers of various diseases has developed in parallel with the recognition of their physiological role.
Due to the functional and morphological heterogeneity of EVs, their separation from complex body fluids, and the detection of disease specific EVs face many challenges. Novel size exclusion and affinity chromatography can be utilized to separate the EVs with diagnostic potential, which supplemented with thorough biochemical and structural characterization can serve the identification of EV-based disease-markers.
The task of the PhD student within this research topic is the isolation of EVs from various body fluids with beyond-state-of-the-art affinity chromatography and the biochemical and physico-chemical description of the vesicle samples with analytical and structural characterization methods (including ATR-FTIR and SAXS).
Required language skills: English (fluent) Further requirements: Basic knowledge in colloid chemsitry and biochemistry, good communication skills, both oral and written english, ability to work in a group, as well as independently
Number of students who can be accepted: 1
Deadline for application: 2017-05-31
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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