Thesis supervisor: Péter Kele
Location of studies (in Hungarian): Research Centre for Natural Sciences, Hungary, 1117 Budapest, Magyar tudósok körútja 2. Abbreviation of location of studies: MTA
Description of the research topic:
Photosensitive materials have attracted interest for drug delivery, super resolution microscopy, photopatterning or information storage. Most photosensitive materials are sensitive to UV light, however, the use of UV irradiation is problematic. In biomedical applications UV light cannot penetrate deeply into tissues and may damage biomatter. Contrary to UV light, near-infrared (NIR) irradiation has significant advantages such as remarkable minimization of photo-damage to biological specimens, maximization of the penetration depth of the excitation light in biological tissue, and an excellent signal-to-noise ratio along with improved detection sensitivity due to the lack of auto-fluorescence from biological materials. Lanthanide-doped nanocrystallyne systems (UCNPs) enable NIR induced anti-Stokes luminescence that can be excited with inexpensive, low-power laser diodes and induce emission of visible light. We aim at conducting a systematic study of the different elements of constructs composed of UCNPs decorated with photolabile-linker anchored drug molecules and homing elements enabling targeted delivery. Such constructs can achieve specific delivery of selected chemotherapeutic agents to targeted cells, where drug release can be effected by NIR light in a controllable manner. Throughout the project we shall study the elements of these constructs: (a) synthesis and evaluation of photolabile linkers, (b) screen for the most efficient UCNP-linker conjugates (c) orthogonal functionalization of UCNPs in order to install photolabile linker-drug conjugates and homing vectors onto their surface and as time allows.
Required language skills: English (fluent) Further requirements: MSc degree in the field of natural or life sciences
Proof of English proficiency
Due to the requirements of the scholarship the applicant should be below 30 years
Number of students who can be accepted: 1
Deadline for application: 2017-05-31
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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