Thesis supervisor: Dániel Érces
co-supervisor: Gabriella Varga
Location of studies (in Hungarian): SZTE ÁOK Sebészeti Műtéttani Intézet Abbreviation of location of studies: SMI
Description of the research topic:
Cardiac tamponade is a severe clinical syndrome which can result in circulatory failure of central origin. Following the splanchnic ischemia, a result of the cardiogenic shock, and the subsequent reperfusion an inflammatory response develops. As a part of the process inflammatory mediators, reactive oxygen- and nitrogen species are released, migration of neutrophil can occur. The inflammatory activation causes the loss of the barrier function of the gastrointestinal mucosa that leads to bacterial translocation and can result in systemic inflammatory response which may develops into sepsis or septic shock.
Methane which previously was considered to be biologically inactive molecule was proved to have an anti-inflammatory effect according to our earlier data. Nonetheless, there are only few data available about the mechanism of action. The aim of our experiments is to investigate the effects of methane inhalation on the macro- and microhemodynamic alterations, on the inflammatory response in a swine model of cardiac tamponade induced cardiogenic shock.
Required language skills: English Number of students who can be accepted: 1
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