Thesis supervisor: Ernő Zádor
Location of studies (in Hungarian): University of Szeged, Faculty of Medicine, Department of Biochemistry,H-6720 Szeged, Dóm tér 9. Abbreviation of location of studies: SZTE
Description of the research topic:
The remodelling means the ongoing reconstruction of cells and tissues while the whole organism appears to be in permanent stage or develops from one stage to an other. In recent years, a lot of regulatory factors have been discuvered in tissue remodelling. The remodelling of skeletal muscle is especially suitable for biochemical and molecular biological studies. The order of activation of signal pathways - transcriptional factors - genes involved in differenciation is well observable. Our group has developed one model in muscle regeneration and two models in muscle adaptation. We have described the mRNA and protein levels of a number of mRNAs and proteins which are regulating factors or a markers of differentiation (i.e.: Neuromusc. Disorders 8: 533-541; J. Muscle Res. and Cell Mot. 20:395-402; J. Muscle Res. & Cell Mot. 21:551-563; Biochem Biophys Res Commun 320:599-605). In these models the aim is to explore the changes and function of molecules and parameters described in the progress of skeletal muscle research.
Required language skills: English Further requirements: TDK munka