Thesis topic proposal
Csilla Csortos
Investigation of the protein phosphatase 1-TIMAP complex in endothelial cells


Institute: University of Debrecen
theoretical medicine
Doctoral School of Molecular Medicine

Thesis supervisor: Csilla Csortos
Location of studies: UD Faculty of Medicine, Institute of Medical Chemistry
Abbreviation of location of studies: DEOVI

Description of the research topic:

The vascular endothelium serves as a selective barrier to fluid and solute flux across the blood vessel walls. Dephosphorylation of phosphoproteins by phospho-Ser/Thr-specific protein phosphatases is crucial in the regulation of endothelial barrier function. Our goal is to learn about the regulatory role of protein phosphatase (PP) 1 on endothelial barrier function in the lung and in the brain, through its regulatory/interacting protein partners. TIMAP (TGFβ-inhibited membrane associated protein), a member of the MYPT family of PP1 targeting subunits, is indeed a regulatory subunit of PP1. While MYPT1 has been extensively studied, much less is known about TIMAP. TGF-β represses TIMAP in endothelial cells, but TGF-β was also shown to be upregulated in the brain in multiple sclerosis, Alzheimer’s disease, stroke, tumors, or trauma. Therefore, our research will be focused on the hypothesis that TIMAP, as a regulatory subunit of PP1, is an active participant in establishment/maintenance of the blood brain barrier. Besides, we aim to widen our knowledge on new protein partners of TIMAP in EC.

Required language skills: English intermediate level
Number of students who can be accepted: 1

Deadline for application: 2016-11-01

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