Thesis supervisor: László Dux
Web address (URL): http://www.biochem.szote.u-szeged.hu/ Location of studies (in Hungarian): Department of Biochemistry, Faculty of Medicine, University of Szeged, H-6720 Szeged, Dóm tér 9., Hungary Abbreviation of location of studies: ÁOK
Description of the research topic:
The programme provides opportunity in research and development of new measurement techniques in pathobiochemistry and clinical biochemistry, standardization and quality control of macromolecular assay methods
In this study LC-IDMS/MS (liquid chromatography isotope-dilution mass spectrometry) procedures for determination of various drug compounds (immunosuppressive, antiretrovirale) in human blood has been developed by using Cs+ adducts in the selected reaction monitoring mode (SRM). The measurement of Cs-adducts in the quantitative HPLC-MS/MS technology resulted in high analytical specificity, accuracy, and precision. The LC-IDMS/MS procedure may be considered as a candidate reference measurement procedure and is appropriate to calibrate analytical routine systems.
Required language skills: English Recommended language skills (in Hungarian): German Number of students who can be accepted: 1
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