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personal data approved: 2016. IV. 15.
Personal data
Attila Ambrus
name Attila Ambrus
year of birth 1973
name of institution
doctoral school
SE János Szentágothai Doctoral School of Neurosciences (Supervisor)
accreditation statement submitted to: Semmelweis University, Budapest
Contact details
E-mail address attila.ambruseok.sote.hu
phone number +36 1 459-1500/60050
own web page
Academic title
scientific degree, title Ph.D.
year degree was obtained 2001
discipline to which degree belongs theoretical medicine
institution granting the degree Debreceni Egyetem (to be translated)
Employment
2006 - Semmelweis University, Budapest
egyetemi kutató
Thesis topic supervisor
number of doctoral students supervised until now 1
number of students who fulfilled course requirements 0
students who obtained their degrees:
present PhD students:
Bálint Nagy (PhD) (2018/08)  JSDSN
Eszter Szabó (PhD) (2018/08)  
Eszter Szabó (PhD) (2018/08)  JSDSN
  Thesis topic proposals
Research
research area Investigation of molecular pathology of mitochondrial alpha-ketoglutarate dehydrogenase multienzyme complex and other dehydrogenase enzymes by modern biochemical, biophysical and structural methods.
research field in which current research is conducted theoretical medicine
biology
Publications
2015

Ambrus A, Nemeria NS, Torocsik B, Tretter L, Nilsson M, Jordan F, Adam-Vizi V: Formation of reactive oxygen species by human and bacterial pyruvate and 2- oxoglutarate dehydrogenase multienzyme complexes reconstituted from recombinant components, FREE RADICAL BIOLOGY AND MEDICINE 89:
type of document: Journal paper/Article
language: English
URL 
2015

Ambrus A, Mizsei R, Adam-Vizi V: Structural alterations by five disease-causing mutations in the low-pH conformation of human dihydrolipoamide dehydrogenase (hLADH) analyzed by molecular dynamics – implications in functional loss and modulation of reactive oxygen species generation by pathogenic hLADH forms, BIOCHEMISTRY AND BIOPHYSICS REPORTS 2:
type of document: Journal paper/Article
language: English
URL 
2014

Nemeria NS, Ambrus A, Patel H, Gerfen G, Adam-Vizi V, Tretter L, Zhou J, Wang J, Jordan F: Human 2-Oxoglutarate Dehydrogenase Complex E1 Component Forms a Thiamin-derived Radical by Aerobic Oxidation of the Enamine Intermediate., JOURNAL OF BIOLOGICAL CHEMISTRY 289: (43)
type of document: Journal paper/Article
number of independent citations: 2
language: English
URL 
2014

Tretter L, Ambrus A: Measurement of ROS homeostasis in isolated mitochondria, METHODS IN ENZYMOLOGY 547:
type of document: Journal paper/Review paper
number of independent citations: 1
language: English
URL 
2013

Ambrus A, Adam-Vizi V: Molecular dynamics study of the structural basis of dysfunction and the modulation of reactive oxygen species generation by pathogenic mutants of human dihydrolipoamide dehydrogenase, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 538: (2)
type of document: Journal paper/Article
number of independent citations: 5
language: English
URL 
2011

Ambrus A, Torocsik B, Tretter L, Ozohanics O, Adam-Vizi V: Stimulation of reactive oxygen species generation by disease-causing mutations of lipoamide dehydrogenase, HUMAN MOLECULAR GENETICS 20: (15)
type of document: Journal paper/Article
number of independent citations: 12
language: English
DOI 
2009

Ambrus A, Tretter L, Adam-Vizi V: Inhibition of the alpha-ketoglutarate dehydrogenase-mediated reactive oxygen species generation by lipoic acid., JOURNAL OF NEUROCHEMISTRY 109: (Suppl 1)
type of document: Journal paper/Konferenciaközlemény
number of independent citations: 15
language: English
DOI 
2009

Dai JX, Ambrus A, Hurley LH, Yang DZ: A Direct and Nondestructive Approach To Determine the Folding Structure of the I-Motif DNA Secondary Structure by NMR, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 131: (17)
type of document: Journal paper/Article
number of independent citations: 21
language: English
DOI 
2006

Ambrus A, Chen D, Dai J, Bialis T, Jones RA, Yang D: Human telomeric sequence forms a hybrid-type intramolecular G-quadruplex structure with mixed parallel/antiparallel strands in potassium solution., NUCLEIC ACIDS RESEARCH 34: (9)
type of document: Journal paper/Article
number of independent citations: 515
language: English
DOI 
2005

Ambrus A, Chen D, Dai J X, Jones R A, Yang D Z: Solution structure of the biologically relevant g-quadruplex element in the human c-MYC promoter. implications for g-quadruplex stabilization, BIOCHEMISTRY 44:
type of document: Journal paper/Article
number of independent citations: 210
language: English
DOI 
Number of independent citations to these publications:781 
Scientometric data
list of publications and citations
number of scientific publications that meet accreditation criteria:
22
number of scientific publications:
24
monographs and professional books:
0
monographs/books in which chapters/sections were contributed:
0 
scientific publications published abroad that meet the accreditation criteria:
21
publications not in Hungarian, published in Hungary, meeting the accreditation criteria:
0
number of independent citations to scientific publications and creative works:
1172
further relevant information regarding accreditation (in Hungarian)
Bolyai Ösztöndíj (2006-2009), Bolyai Plakett (2010), Fulbright Fellowship (Rutgers University, 2012), EMBO Short-term Fellowship (University of Pittsburgh, 2011), The Protein Society Finn Wold Travel Award (2011), Bolyai Ösztöndíj (2011-2014) (to be translated)

 
All rights reserved © 2007, Hungarian Doctoral Council. Doctoral Council registration number at commissioner for data protection: 02003/0001. Program version: 1.2318 ( 2016. XI. 26. )