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personal data approved: 2016. II. 02.
Personal data
name Tamás Hegedűs
year of birth 1974
name of institution
doctoral school
ELTE Doctoral School of Biology (Academic staff member)
SE Doctoral School of Basic Medicine (Announcer of research topic)
the share of work in the different doctoral schools. ELTE Doctoral School of Biology 50%
SE Doctoral School of Basic Medicine 50%
accreditation statement submitted to: Eötvös Loránd University, Budapest
Contact details
E-mail address tamashegelab.org
phone number +36 1 459-1500/60230
own web page
Academic title
scientific degree, title Ph.D.
year degree was obtained 2003
discipline to which degree belongs biology
institution granting the degree ELTE (to be translated)
Employment
2012 - MTA-SE Molekuláris Biofizikai Kutatócsoport (research institute, not university)
other (not specified) (főmunkatárs)
Thesis topic supervisor
number of doctoral students supervised until now 1.5
number of students who fulfilled course requirements 0.5
students who obtained their degrees:
(50%) Gergely Gyimesi PhD 2011  DSBM-SE

  Thesis topic proposals
Research
research area Investigation of the structure and dynamics of ABC proteins including multidrug transporters and the Cystic Fibrosis Transmembrane Conductance Regulator.
research field in which current research is conducted biology
Publications
2016

Szollosi D, Erdei A, Gyimesi G, Magyar C, Hegedus T: Access Path to the Ligand Binding Pocket May Play a Role in Xenobiotics Selection by AhR., PLOS ONE 11: (1) p. e0146066.
type of document: Journal paper/Article
language: English
DOI 
2015

Tóth A, Brózik A, Szakács G, Sarkadi B, Hegedûs T: A novel mathematical model describing adaptive cellular drug metabolism and toxicity in the chemoimmune system, PLOS ONE 10: (2) p. e0115533.
type of document: Journal paper/Article
language: English
URL 
2015

Hegedus T, Chaubey PM, Varady G, Szabo E, Saranko H, Hofstetter L, Roschitzki B, Stieger B, Sarkadi B: Inconsistencies in the red blood cell membrane proteome analysis: generation of a database for research and diagnostic applications., DATABASE-JOURNAL OF BIOLOGICAL DATABASES AND CURATION 2015: p. bav056.
type of document: Journal paper/Article
language: English
URL 
2014

Veit G, Avramescu RG, Perdomo D, Phuan PW, Bagdany M, Apaja PM, Borot F, Szollosi D, Wu YS, Finkbeiner WE, Hegedus T, Verkman AS, Lukacs GL: Some gating potentiators, including VX-770, diminish ΔF508-CFTR functional expression, SCIENCE TRANSLATIONAL MEDICINE 6: (246) p. 246ra97.
type of document: Journal paper/Article
number of independent citations: 32
language: English
DOI 
2013

Saranko H, Tordai H, Telbisz A, Ozvegy-Laczka C, Erdos G, Sarkadi B, Hegedus T: Effects of the gout-causing Q141K polymorphism and a CFTR DeltaF508 mimicking mutation on the processing and stability of the ABCG2 protein., BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 437: (1) pp. 140-145.
type of document: Journal paper/Article
number of independent citations: 8
language: English
URL 
2013

Hegedus T, Gyimesi G, Gaspar ME, Szalay KZ, Gangal R, Csermely P: Potential application of network descriptions for understanding conformational changes and protonation states of ABC transporters., CURRENT PHARMACEUTICAL DESIGN 19: (23) pp. 4155-4172. Paper 23170883.
type of document: Journal paper/Article
impact factor: 3.288
number of independent citations: 4
language: English
Full text 
2013

Okiyoneda T, Veit G, Dekkers J F, Bagdany M, Soya N, Xu H, Roldan A, Verkman A S, Kurth M, Simon A, Hegedus T, Beekman J M, Lukacs G L: Mechanism-based corrector combination restores ΔF508-CFTR folding and function., NATURE CHEMICAL BIOLOGY 9: pp. 444-454.
type of document: Journal paper/Article
number of independent citations: 75
language: English
URL 
2012

Gyimesi G, Ramachandran S, Kota P, Dokholyan NV, Sarkadi B, Hegedus T: ATP hydrolysis at one of the two sites in ABC transporters initiates transport related conformational transitions (vol 1808, pg 2954, 2011), BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES 1818: (5) p. 1435.
type of document: Journal paper/Article
impact factor: 3.389
language: English
DOI 
2012

Gyimesi G, Borsodi D, Saranko H, Tordai H, Sarkadi B, Hegedus T: ABCMdb: a database for the comparative analysis of protein mutations in ABC transporters, and a potential framework for a general application., HUMAN MUTATION 33: (11) pp. 1547-1556. Paper 22693078.
type of document: Journal paper/Article
impact factor: 5.213
number of independent citations: 3
language: English
DOI 
2002

Hegedus T, Orfi L, Seprodi A, Varadi A, Sarkadi B, Keri G: Interaction of tyrosine kinase inhibitors with the human multidrug transporter proteins, MDR1 and MRP1., BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1587: (2-3) pp. 318-325.
type of document: Journal paper/Review paper
number of independent citations: 140
language: English
DOI 
Number of independent citations to these publications:262 
Scientometric data
list of publications and citations
number of scientific publications that meet accreditation criteria:
40
number of scientific publications:
48
monographs and professional books:
0
monographs/books in which chapters/sections were contributed:
2 
number of independent citations to scientific publications and creative works:
1499

 
All rights reserved © 2007, Hungarian Doctoral Council. Doctoral Council registration number at commissioner for data protection: 02003/0001. Program version: 1.2318 ( 2016. XI. 26. )