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personal data approved: 2017. II. 10.
Personal data
name Csilla Laczka
year of birth 1974
name of institution
doctoral school
ELTE Doctoral School of Biology (Announcer of research topic)
SE Doctoral School of Molecular Medicine (Announcer of research topic)
the share of work in the different doctoral schools. ELTE Doctoral School of Biology 50%
SE Doctoral School of Molecular Medicine 50%
accreditation statement submitted to: Eötvös Loránd University, Budapest
Contact details
E-mail address lozvegybiomembrane.hu
phone number +36 1 382-6789
own web page
Academic title
scientific degree, title Ph.D.
year degree was obtained 2003
discipline to which degree belongs biology
institution granting the degree Eötvös Loránd University os Sciences
Employment
2013 - Enzimológiai Intézet, TTK, MTA (research institute, not university)
other (not specified) (tudományos főmunkatárs)
Thesis topic supervisor
number of doctoral students supervised until now 1.5
number of students who fulfilled course requirements 0.5
students who obtained their degrees:
(50%) Csilla Hegedüs PhD 2014  DSB-ELTE

present PhD students:
Izabel Patik (PhD) (2017/08)  
  Thesis topic proposals
Research
research area Investigation of the transport mechanism, structure-function relationship and regulation of ABC (ATP Binding Cassette) proteins and organic anion transporting polipeptides (OATP).
research field in which current research is conducted biology
Publications
2015

Patik I, Kovacsics D, Nemet O, Gera M, Varady G, Stieger B, Hagenbuch B, Szakacs G, Ozvegy-Laczka C: Functional Expression of the 11 Human Organic Anion Transporting Polypeptides in Insect Cells Reveals that Sodium Fluorescein is a General OATP Substrate., BIOCHEMICAL PHARMACOLOGY 98: (4) pp. 649-658.
type of document: Journal paper/Article
language: English
DOI 
2015

Gál Z, Hegedüs C, Szakács G, Váradi A, Sarkadi B, Özvegy-Laczka C: Mutations of the central tyrosines of putative cholesterol recognition amino acid consensus (CRAC) sequences modify folding, activity, and sterol-sensing of the human ABCG2 multidrug transporter, BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES 1848: (2) pp. 477-487.
type of document: Journal paper/Article
number of independent citations: 2
language: English
URL 
2015

Hegedüs C, Telbisz A, Hegedus T, Sarkadi B, Özvegy-Laczka C: Lipid Regulation of the ABCB1 and ABCG2 Multidrug Transporters, ADVANCES IN CANCER RESEARCH 125: pp. 97-137.
type of document: Journal paper/Article
number of independent citations: 3
language: English
URL 
2014

Telbisz A, Hegedus C, Varadi A, Sarkadi B, Ozvegy-Laczka C: Regulation of the Function of the Human ABCG2 Multidrug Transporter by Cholesterol and Bile Acids: Effects of Mutations in Potential Substrate- And Steroid-Binding Sites., DRUG METABOLISM AND DISPOSITION 42: (4) pp. 575-585.
type of document: Journal paper/Article
number of independent citations: 9
language: English
URL 
2012

Telbisz A, Hegedus C, Ozvegy-Laczka C, Goda K, Varady G, Takats Z, Szabo E, Sorrentino BP, Varadi A, Sarkadi B: Antibody binding shift assay for rapid screening of drug interactions with the human ABCG2 multidrug transporter., EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 45: (1-2) pp. 101-109.
type of document: Journal paper/Article
number of independent citations: 5
language: English
URL 
2012

Hegedűs C, Truta-Feles K, Antalffy G, Várady G, Német K, Özvegy-Laczka C, Kéri G, Orfi L, Szakács G, Settleman J, Váradi A, Sarkadi B: Interaction of the EGFR inhibitors gefitinib, vandetanib, pelitinib and neratinib with the ABCG2 multidrug transporter: Implications for the emergence and reversal of cancer drug resistance, BIOCHEMICAL PHARMACOLOGY 84: (3) pp. 260-267.
type of document: Journal paper/Article
number of independent citations: 27
language: English
DOI 
2011

Brozik A, Hegedus C, Erdei Z, Hegedus T, Ozvegy-Laczka C, Szakacs G, Sarkadi B: Tyrosine kinase inhibitors as modulators of ATP binding cassette multidrug transporters: substrates, chemosensitizers or inducers of acquired multidrug resistance?, EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY 7: (5) pp. 623-642.
type of document: Journal paper/Article
number of independent citations: 51
language: English
DOI 
2009

Hegedus C, Ozvegy-Laczka C, Apati A, Magocsi M, Nemet K, Orfi L, Keri G, Katona M, Takats Z, Varadi A, Szakacs G, Sarkadi B: Interaction of nilotinib, dasatinib and bosutinib with ABCB1 and ABCG2: implications for altered anti-cancer effects and pharmacological properties., BRITISH JOURNAL OF PHARMACOLOGY 158: (4) pp. 1153-1164.
type of document: Journal paper/Article
number of independent citations: 132
language: English
DOI 
2008

Ozvegy-Laczka C, Laczko R, Hegedus C, Litman T, Varady G, Goda K, Hegedus T, Dokholyan NV, Nikolay V, Sorrentino BP, Varadi A, Sarkadi B: Interaction with the 5D3 monoclonal antibody is regulated by intramolecular rearrangements but not by covalent dimer formation of the human ABCG2 multidrug transporter, JOURNAL OF BIOLOGICAL CHEMISTRY 283: (38) pp. 26059-26070.
type of document: Journal paper/Article
number of independent citations: 16
language: English
DOI 
2005

Elkind N B, Szentpetery Z, Apati A, Ozvegy-Laczka C, Varady G, Ujhelly O, Szabo K, Homolya L, Varadi A, Buday L, Keri G, Nemet K, Sarkadi B: Multidrug transporter ABCG2 prevents tumor cell death induced by the epidermal growth factor receptor inhibitor Iressa (ZD1839, Gefitinib)., CANCER RESEARCH 65: (5) pp. 1770-1777.
type of document: Journal paper/Article
number of independent citations: 173
language: English
DOI 
Number of independent citations to these publications:418 
Scientometric data
list of publications and citations
number of scientific publications that meet accreditation criteria:
29
number of scientific publications:
48
monographs and professional books:
0
monographs/books in which chapters/sections were contributed:
0 
number of independent citations to scientific publications and creative works:
2089
further relevant information regarding accreditation (in Hungarian)
Postdoctoral fellowship of OTKA 2003, The award of Qualitas Biologica Fund for Ph.D. thesis 2003, Bolyai János fellowship of the Hungarian Academy of Scinces 2004, Scientific Award by the Hungarian Academy of Sciences for Young Researchers 2005., Farkas Tibor award for young membrane researchers 2007., Award from L’Oreal-Unesco for Women in Science 2008., Publication award by Sigma-Aldrich Ltd. 2009.


2017. III. 21.
ODT ülés
Az ODT következő ülésére 2017. május 5-én 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).

 
All rights reserved © 2007, Hungarian Doctoral Council. Doctoral Council registration number at commissioner for data protection: 02003/0001. Program version: 1.2343 ( 2017. II. 28. )