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personal data approved: 2016. IX. 19.
Personal data
László Őrfi
name László Őrfi
year of birth 1957
name of institution
doctoral school
BME George A. Olah Doctoral School of Chemistry and Chemical Technology (Academic staff member)
(discipline) Habilitation Comittee and Doctoral Council (external member)
SE Doctoral School of Pharmaceutical Sciences (Supervisor)
SE Doctoral School of Molecular Medicine (Announcer of research topic)
the share of work in the different doctoral schools. BME George A. Olah Doctoral School of Chemistry and Chemical Technology 10%
SE Doctoral School of Pharmaceutical Sciences 50%
SE Doctoral School of Molecular Medicine 20%
BME GAODSCC (discipline) Habilitation Comittee and Doctoral Council (external member) 20%
accreditation statement submitted to: Semmelweis University, Budapest
Contact details
E-mail address orfi.laszlopharma.semmelweis-univ.hu
phone number +36 1 217-0891
own web page
Academic title
scientific degree, title Ph.D.
year degree was obtained 1997
discipline to which degree belongs chemistry
institution granting the degree Semmelweis University
scientific degree, title Habilitation
year degree was obtained 2013
discipline to which degree belongs pharmaceutics
institution granting the degree Semmelweis University
Employment
1982 - Semmelweis University, Budapest
university professor or researcher
Thesis topic supervisor
number of doctoral students supervised until now 8
number of students who fulfilled course requirements 5
students who obtained their degrees:
Ferenc Baska PhD 2015  DSPS1-SE
Gábor Németh PhD 2012  
Gábor Péter Bánhegyi PhD 2009  DSPS1-SE
Csaba Szántai-Kis PhD 2008  

students with degree granting in process:
Rita Garamvölgyi PhD (2016/10)  DSPS1-SE
Zoltán Nemes PhD (2018/12)  DSPS1-SE
present PhD students:
Zsófia Czudor (PhD) (2018/08)  DSPS1-SE
  Thesis topic proposals
Research
research area Pharmaceutical chemistry, kinase inhibitors, quantitative structure-activity relationship (QSAR, ADMET), drug design, lead optimisation, drug discovery, medicinal chemistry, paralell synthesis
research field in which current research is conducted pharmaceutics
chemistry
Publications
2016

Garamvolgyi R, Dobos J, Sipos A, Boros S, Illyes E, Baska F, Kekesi L, Szabadkai I, Szantai-Kis C, Keri G, Orfi L: Design and synthesis of new imidazo[1,2-a]pyridine and imidazo[1,2-a]pyrazine derivatives with antiproliferative activity against melanoma cells., EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 108: pp. 623-643.
type of document: Journal paper/Article
language: English
DOI 
2015

Herrero Ana, Pinto Adan, Colon-Bolea Paula, Casar Berta, Jones Mary, Agudo-Ibanez Lorena, Vidal Rebeca, Tenbaum Stephan P, Nuciforo Paolo, Valdizan Elsa M, Horvath Zoltan, Orfi Laszlo, Pineda-Lucena Antonio, Bony Emilie, Keri Gyorgy, Rivas German, Pazos Angel, Gozalbes Rafael, Palmer Hector G, Hurlstone Adam, Crespo Piero: Small Molecule Inhibition of ERK Dimerization Prevents Tumorigenesis by RAS-ERK Pathway Oncogenes, CANCER CELL 28: (2) pp. 170-182.
type of document: Journal paper/Article
number of independent citations: 8
language: English
DOI 
2014

Baska Ferenc, Szabadkai István, Sipos Anna, Breza Nóra, Szántai-Kis Csaba, Kékesi László, Garamvölgyi Rita, Nemes Zoltán, Baska Ferenc, Neumann Lars, Torka Robert, Ullrich Axel, Kéri György, Őrfi László: Pharmacophore and Binding Analysis of Known and Novel B-RAF Kinase Inhibitors, CURRENT MEDICINAL CHEMISTRY 21: (17) pp. 1938-1955.
type of document: Journal paper/Article
number of independent citations: 5
language: English
URL 
2014

Németh Gábor, Greff Zoltán, Sipos Anna, Varga Zoltán, Székely Rita, Sebestyén Mónika, Jászay Zsuzsa, Béni Szabolcs, Nemes Zoltán, Pirat Jean-Luc, Volle Jean-Noël, Virieux David, Gyuris Ágnes, Kelemenics Katalin, Áy Éva, Minarovits Janos, Szathmary Susan, Kéri György, Őrfi László: Synthesis and Evaluation of Phosphorus Containing, Specific CDK9/CycT1 Inhibitors, JOURNAL OF MEDICINAL CHEMISTRY 57: (10) pp. 3939-3965.
type of document: Journal paper/Article
number of independent citations: 15
language: English
URL 
2011

Nemeth G, Varga Z, Greff Z, Bencze G, Sipos A, Szantai-Kis C, Baska F, Gyuris A, Kelemenics K, Szathmary Z, Minarovits J, Keri G, Orfi L: Novel, Selective CDK9 Inhibitors for the Treatment of HIV Infection, CURRENT MEDICINAL CHEMISTRY 18: (3) pp. 342-358.
type of document: Journal paper/Review paper
number of independent citations: 14
language: English
2010

Petak I, Schwab R, Orfi L, Kopper L, Keri G: Integrating molecular diagnostics into anticancer drug discovery, NATURE REVIEWS DRUG DISCOVERY 9: (7) pp. 523-535.
type of document: Journal paper/Article
number of independent citations: 34
language: English
DOI 
2004

Ozvegy-Laczka C, Hegedus T, Varady G, Ujhelly O, Schuetz JD, Varadi A, Keri G, Orfi L, Nemet K, Sarkadi B: High-affinity interaction of tyrosine kinase inhibitors with the ABCG2multidrug transporter, MOLECULAR PHARMACOLOGY 65: (6) pp. 1485-1495.
type of document: Journal paper/Article
number of independent citations: 255
language: English
DOI 
2002

Hegedus T, Orfi L, Seprodi A, Varadi A, Sarkadi B, Keri G: Interaction of tyrosine kinase inhibitors with the human multidrug transporter proteins, MDR1 and MRP1., BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1587: (2-3) pp. 318-325.
type of document: Journal paper/Review paper
number of independent citations: 173
language: English
DOI 
1998

Orfi L, Lin MF, Larive CK: Measurement of SDS micelle-peptide association using H-1 NMR chemical shift analysis and pulsed field gradient NMR spectroscopy, ANALYTICAL CHEMISTRY 70: (7) pp. 1339-1345.
type of document: Journal paper/Article
number of independent citations: 51
language: English
DOI 
1996

Strawn LM, McMahon G, App H, Schreck R, Kuchler WR, Longhi MP, Hui TH, Tang C, Levitzki A, Gazit A, Chen I, Keri G, Orfi L, Risau W, Flamme I, Ullrich A, Hirth KP, Shawver LK: Flk-1 as a Target for Tumor Growth Inhibition, CANCER RESEARCH 56: (15) pp. 3540-3345.
type of document: Journal paper/Article
number of independent citations: 337
language: English
URL 
Number of independent citations to these publications:892 
Scientometric data
list of publications and citations
number of scientific publications that meet accreditation criteria:
163
number of scientific publications:
198
monographs and professional books:
0
monographs/books in which chapters/sections were contributed:
2 
scientific publications published abroad that meet the accreditation criteria:
97
publications not in Hungarian, published in Hungary, meeting the accreditation criteria:
49
number of independent citations to scientific publications and creative works:
2348
further relevant information regarding accreditation (in Hungarian)
Inventor of 98 pharmaceutical patents

 
All rights reserved © 2007, Hungarian Doctoral Council. Doctoral Council registration number at commissioner for data protection: 02003/0001. Program version: 1.2318 ( 2016. XI. 26. )