Attila Ambrus - ODT Personal data sheet


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Personal data sheet

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personal data approved: 2023. IX. 08.

Personal data

name	Attila Ambrus
name of institution	Semmelweis University, Budapest
doctoral school	SE János Szentágothai Doctoral School of Neurosciences (Academic staff member Az oktató a doktori iskola doktoranduszai számára oktat tantárgyat, és/vagy a doktori iskola megszavazta, hogy doktoranduszok számára kutatási témát írjon ki. ) SE Doctoral School of University Semmelweis (Academic staff member Az oktató a doktori iskola doktoranduszai számára oktat tantárgyat, és/vagy a doktori iskola megszavazta, hogy doktoranduszok számára kutatási témát írjon ki. )
the share of work in the different doctoral schools.	SE Doctoral School of University Semmelweis 100%
accreditation statement submitted to:	Semmelweis University, Budapest

Contact details
phone number	+36 1 459-1500/60050
	own web page

Academic title
scientific degree, title	Ph.D.
year degree was obtained	2001
discipline to which degree belongs	theoretical medicine
institution granting the degree	University of Debrecen
scientific degree, title	DSc
year degree was obtained	2022
discipline to which degree belongs	biology
institution granting the degree	HAS
scientific degree, title	Habilitation
year degree was obtained	2022
discipline to which degree belongs	theoretical medicine
institution granting the degree	Semmelweis University

Employment
2006 -	Semmelweis University, Budapest university professor or researcher

Thesis topic supervisor

number of doctoral students supervised until now

4.5

number of students who fulfilled course requirements

students who obtained their degrees:

Bálint Nagy	PhD	2023	JSDSN
Réka Mizsei	PhD	2021	JSDSN
Eszter Szabó	PhD	2020	JSDSN

Thesis topic proposals

Research
research area	Investigation of molecular pathology of mitochondrial alpha-ketoglutarate dehydrogenase multienzyme complex and other dehydrogenase enzymes by modern biochemical, biophysical and structural methods.
research field in which current research is conducted	theoretical medicine biology

Publications

2023

Ozohanics Oliver, Zhang Xu, Nemeria Natalia S., Ambrus Attila, Jordan Frank: Probing the E1o-E2o and E1a-E2o Interactions in Binary Subcomplexes of the Human 2-Oxoglutarate Dehydrogenase and 2-Oxoadipate Dehydrogenase Complexes by Chemical Cross-Linking Mass Spectrometry and Molecular Dynamics Simulation, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 24: (5) 4555
type of document: Journal paper/Article
language: English
URL

2023

Szabo E., Nemes-Nikodem E., Vass K.R., Zambo Z., Zrupko E., Torocsik B., Ozohanics O., Nagy B., Ambrus A.: Structural and Biochemical Investigation of Selected Pathogenic Mutants of the Human Dihydrolipoamide Dehydrogenase, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 24: (13) 10826
type of document: Journal paper/Article
language: English
URL

2021

Nagy Balint, Polak Martin, Ozohanics Oliver, Zambo Zsofia, Szabo Eszter, Hubert Agnes, Jordan Frank, Novaček Jiří, Adam-Vizi Vera, Ambrus Attila: Structure of the dihydrolipoamide succinyltransferase (E2) component of the human alpha-ketoglutarate dehydrogenase complex (hKGDHc) revealed by cryo-EM and cross-linking mass spectrometry, BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 1865: (6) 129889
type of document: Journal paper/Article
number of independent citations: 9
language: English
URL

2019

Szabo Eszter, Wilk Piotr, Nagy Balint, Zambo Zsofia, Bui David, Weichsel Andrzej, Arjunan Palaniappa, Torocsik Beata, Hubert Agnes, Furey William, Montfort William R, Jordan Frank, Weiss Manfred S, Adam-Vizi Vera, Ambrus Attila: Underlying molecular alterations in human dihydrolipoamide dehydrogenase deficiency revealed by structural analyses of disease-causing enzyme variants, HUMAN MOLECULAR GENETICS 28: (20) pp. 3339-3354.
type of document: Journal paper/Article
number of independent citations: 12
language: English
URL

2019

Ambrus Attila: An updated view on the molecular pathomechanisms of human dihydrolipoamide dehydrogenase deficiency in light of novel crystallographic evidence, NEUROCHEMICAL RESEARCH 44: (10) pp. 2307-2313.
type of document: Journal paper/Article
number of independent citations: 6
language: English
URL

2018

Szabo E, Mizsei R, Wilk P, Zambo Z, Torocsik B, Weiss MS, Adam-Vizi V, Ambrus A: Crystal structures of the disease-causing D444V mutant and the relevant wild type human dihydrolipoamide dehydrogenase, FREE RADICAL BIOLOGY AND MEDICINE 124: pp. 214-220.
type of document: Journal paper/Article
number of independent citations: 5
language: English
URL

2015

Ambrus A, Nemeria NS, Torocsik B, Tretter L, Nilsson M, Jordan F, Adam-Vizi V: Formation of reactive oxygen species by human and bacterial pyruvate and 2- oxoglutarate dehydrogenase multienzyme complexes reconstituted from recombinant components, FREE RADICAL BIOLOGY AND MEDICINE 89: pp. 642-650.
type of document: Journal paper/Article
number of independent citations: 28
language: English
URL

2011

Ambrus A, Torocsik B, Tretter L, Ozohanics O, Adam-Vizi V: Stimulation of reactive oxygen species generation by disease-causing mutations of lipoamide dehydrogenase, HUMAN MOLECULAR GENETICS 20: (15) pp. 2984-2995.
type of document: Journal paper/Article
number of independent citations: 27
language: English
URL

2009

Ambrus A, Tretter L, Adam-Vizi V: Inhibition of the alpha-ketoglutarate dehydrogenase-mediated reactive oxygen species generation by lipoic acid, JOURNAL OF NEUROCHEMISTRY 109: (Suppl. 1) pp. 222-229.
type of document: Journal paper/Article
number of independent citations: 33
language: English
URL

2006

Ambrus A, Chen D, Dai J, Bialis T, Jones RA, Yang D: Human telomeric sequence forms a hybrid-type intramolecular G-quadruplex structure with mixed parallel/antiparallel strands in potassium solution., NUCLEIC ACIDS RESEARCH 34: (9) pp. 2723-2735.
type of document: Journal paper/Article
number of independent citations: 923
language: English
URL

Number of independent citations to these publications:

1043

Scientometric data

list of publications and citations

number of scientific publications that meet accreditation criteria:

number of scientific publications:

monographs and professional books:

monographs/books in which chapters/sections were contributed:

scientific publications published abroad that meet the accreditation criteria:

publications not in Hungarian, published in Hungary, meeting the accreditation criteria:

number of independent citations to scientific publications and creative works:

2555

further relevant information regarding accreditation (in Hungarian)
Bolyai Fellowship (2006-2009), Bolyai Plaquette (2010), Fulbright Fellowship (Rutgers University, 2012), EMBO Short-term Fellowship (University of Pittsburgh, 2011), The Protein Society Finn Wold Travel Award (2011), Bolyai Fellowship (2011-2014), Merit Prize (2016), Merit Prize (2019), Merit Prize (2023)